Endocrine Abstracts

Aldosterone-secreting adrenocortical carcinoma (ACC) is rare neoplasm, which detected in 2.5% of active ACCs.Clinical case: A 58 years old female, was admitted to our clinic with complaints of high blood pressure, back pain, weakness, convulsions. Biochemical evaluation confirmed primary hyperaldosteronism (serum aldosterone 1012 pg\ml, serum renin concentration 0.5 mkME\ml, aldosterone-renin ratio 202.4, hypokalemia 1.2 mmol\l). There was no evidence of...

Parathyroid carcinoma is a rare cause of primary hyperparathyroidism (PHPT) and is usually presented with severe hypercalcaemia and parathyroid hormone (PTH) elevation. Hypercalcaemia can lead to calcification of parenchymatous organs, including pancreas, and acute or chronic pancreatitis.Case report: A 46-year-old woman was admitted to the endocrine surgery department of our institution with severe weakness, appetite and weight loss (25 kg in a year), a...

According to the 4th edition of the WHO classification of endocrine organ tumors (2017), all pheochromocytomas are classified as malignant tumors (ICD-O code 8700/3). However, in the literature there are no unambiguous data on the significance of clinical and laboratory predictors of the aggressiveness of pheochromocytoma. The aim of the study was to verify possible predictors of pheo-progression using clinical data, the results of laboratory and instrumental examination (incl...

Adrenocortical cancer (ACC) is a tumor of the adrenal cortex, clinical manifestations, recurrence, and progression potential are determined by its biological characteristics. Morphological diagnosis of tumors of the adrenal glands in some cases presents significant difficulties. According to the WHO classification of tumors of the endocrine organs (4th revision, 2017), in addition to the classical one, myxoid, sarcomatoid and oncocytic histological variants of ACC are distingu...

Neuroendocrine neoplasias (NENs) are a heterogeneous group of tumors that differ in appearance, growth patterns, and clinical symptoms and develop from neuroendocrine cells and, accordingly, unusually similar cytological characteristics. Pheochromocytoma is considered as not epithelial type of NENs. We would like to present a clinical case of pheochromocytoma with difficulties in laboratory diagnosis and morphological verification. Female patient P., 60 years old, for 10 years...

Renal cell carcinoma metastases to adrenal glands are indicative of a generalized tumor process, but in cases of solitary metastases, a radical surgical treatment of these patients is possible.The object of the present study was an estimation of the remote outcome of surgical treatment of 18 patients with solitary renal cell carcinoma metastases to adrenal glands operated on in our clinic over the period from 1999 to 2008. Among them, there were 6 men an...

The aim of the study was analysis of long-term results of surgical treatment in patients with adrenocortical carcinoma as well as definition of prognostic factors.From 1998 to 2008, examination and treatment of 53 patients with adrenocortical carcinoma (31 women and 22 men, mean age 52.8 years) was carried out in our institute: 13 patients had Cushing syndrome, 1 – virilization, 2 – total adrenohypercortisolism, and 37 – nonfunctioning tum...

From 1987 to 2008, 226 patients were operated on for primary hyperparathyroidism (pHPT). In 17 (men and women, aged 21–71 years) of them, parathyroid carcinoma (PC) was verified by histologic analysis. Mixed pHPT form was noted in 12 patients, visceropathic one – in 4, and asymptomatic – in 1. Hypercalcemia was revealed in 14 of 17 patients, and elevation of parathyroid hormone (PTH) level (426–1160 pg/ml) – in 12. In 5 patients operated on before 1990...

The aim of the study was investigating of microvessels density (MD) and expression of vascular endothelial growth factor (VEGF) in adrenocortical tumors.Under investigation there were 23 adrenocortical tumors: adenomas – 13, ‘border’ tumors – 4, and carcinomas – 6. Immunohistochemical studied were carried out using monoclonal antibodies to both VEGF and endothelial marker CD34 (Dako). VEGF expression was estimated as a weak one (...

Adrenocortical carcinoma is a rare tumor characterized aggressive growth and poor prognosis. This tumor requires the complex way of treatment, where basic method is surgery.The aim of this study was to evaluate the long-term outcome and role of surgery in patients with adrenocortical carcinoma.Methods: From 1998 to 2007, 44 patients were operated for adrenocortical carcinoma (14 cortisol-secreting tumors, 1 virilizing tumor and 29 ...